The University of Chicago Chemistry Department seminars were held on Mondays in Kent Hall, an old building where the floors creaked and there was a smell of dust and mildew. Only the most distinguished scientists were invited to speak at this seminar, many had Nobel prizes or were to receive one, and the list included Franck, Urey, Calvin, Seaborg, Eigen, Libby and Taube.

But this day was different because a second year graduate student, Stanley Lloyd Miller, was speaking, and the room was full because the word had spread that something important was to be presented. In addition to the famous scientists and less famous but equally high-powered scientists was an undergraduate, Carl Sagan attending his first chemistry seminar. The topic was the synthesis of important biological compounds, using conditions thought to have existed on the primitive Earth.

Miller reported that by sending repeated electric sparks through a sealed flask containing a mixture of methane, ammonia, hydrogen, and water vapor, he had made some of the amino acids found in proteins. Perhaps, he suggested, this was how organic compounds were made on the ancient Earth before life existed.

While Miller was confident of his results, the rows of famous faces in his audience were, to say the least, intimidating. He was bombarded with questions. Were the analyses done correctly? Could there have been contamination? After the event, Miller thought that the questions had been constructive, but since the results were hard to believe, they had simply wanted to ensure that he had not made some mistake. However, Carl Sagan thought that Miller's inquisitors seemed to be picky and did not appreciate the significance of the experiment. Even the relevance of Miller's results to the origin of life were questioned. When someone asked Miller how he could really be sure this kind of process actually took place on the primitive Earth, Nobel Laureate Harold Urey, Miller's research advisor, immediately interrupted, replying, "If God did not do it this way, then he missed a good bet." The seminar ended amid the laughter, and the attendees filed out with some making complimentary remarks to Miller. Miller changed clothes, went back to the lab and started a paper chromatography run.

The events leading up to this dramatic seminar began two years earlier in October, 1951 when Urey presented the Chemistry Department seminar on the origin of the solar system. In addition to the usual high powered scientists, the audience had contained the then first year graduate student, Stanley Miller.

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